VANCOMYCIN

Indication	Dose	Frequency	Cost
Gram-postive infections	1 gram	Q12 hours
Native valve endocarditis in penicillin and beta-lactam allergic patients caused by streptococci	30 mg/kg/day	in 2 divided doses for 4 weeks
Native valve endocarditis in penicillin and beta-lactam allergic patients or methacillin-resistant staphylococci caused by Staphylococcus aureus or Staphylococcus epidermidis	30 mg/kg/day	in 2 divided doses for 4-6 weeks
Native valve endocarditis in penicillin and beta-lactam allergic patients caused by Enterococcus faecalis and Enterococcus faecium	30 mg/kg/day	in 2 divided doses for 4-6 weeks
Prosthetic valve endocarditis in penicillin and beta-lactam allergic patients or patients with methicillin-resistant staphylococci caused by coagulase-negative Staphylococci and Staphylococcus aureus	30 mg/kg/day	in 2 or 4 divided doses for 6 weeks
Meningitis	2-4 grams	divided in 2-4 doses

Weight (kg)	Dose	Creatinine Clearance	Frequency
>90	1500 mg	Crcl >100 ml/min	Q12 hours
76-89	1250 mg	Crcl 80-99 ml/min	Q18 hours
58-75	1000 mg	Crcl 60-79 ml/min	Q24 hours
42-57	750 mg	Crcl 40-59 mlmin	Q36 hours
25-41	500 mg	Crcl 25-39 ml/min	Q48 hours
		Crcl <25 ml/min	15 mg/kg initial dose and adjust dose and interval based on trough levels