TRIMETHOPRIM /SULFAMETHOXAZOLE
Normal Dose|Renal Impairment|Hemodialysis
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| Indication | Dose | Frequency | Cost |
| Urinary tract infections | 160 mg/800 mg (po) | Q12 hours for 10-14 days | |
| Pneumocystis carinii pneumonia | 15-20 mg trimethoprim/ 75-100 mg sulfamethoxazole/ kg / day (po) | divide dose Q6 hours for 14-21 days | |
| AIDS | 15-20 mg trimethoprim/ 75-100 mg sulfamethoxazole/ kg /day (inj) | divide dose in 3 or 4 doses for 21 days | |
| Prophylaxis of pneumocystis carinii pneumonia | 160 mg /800 mg (po) | Q24 hours | |
| Shigellosis | 160 mg/800 mg (po)
8-10 mg trimethoprim / 40-50 mg sulfamethoxazole / kg /day (inj) |
Q12 hours
2 to 4 equally divided doses Q6, 8, or 12 hours for 5 days |
|
| Exacerbations of chronic bronchitis | 160 mg/800 mg | Q12 hours for 14 days | |
| Cystic fibrosis with acute pulmonary exacerbations | 5 mg/kg trimethoprim 25 mg/kg sulfamethoxazole | Q6 hours | |
| Cystic fibrosis to suppress the growth of Burkholderia cepacia | 160 mg/800 mg | Q12 hours | |
| Cyclospora infection | 160 mg/800 mg | QID for 10 days followed by prophylaxis with 1 tablet 3 times weekly | |
| Acute maxillary sinusitis | 160 mg/800 mg | BID for 10 days | |
| Travelers' Diarrhea | 160 mg/800 mg | Q12 hours for 5 days |
| Creatinine Clearance | Dose and Frequency |
| Crcl >30 ml/min | standard regimen |
| Crcl 15-30 ml/min | 1/2 standard regimen |
| Crcl <15 ml/min | not recommended |
| Dose and Frequency |
| 50% of the maintenance dose of trimethoprim/sulfamethoxazole should be supplemented following each dialysis session |