Normal Dose|Renal Impairment|Hemodialysis
_____________________________________________________________
| Indication | Dose | Frequency | Cost |
| Pulmonary tuberculosis | 15 mg/kg | Q24 hours | |
| Extrapulmonary tuberculosis | 15 mg/kg | Q24 hours | |
| Tularemia | 1-2 grams/day | in divided doses for 7-14 days | |
| Plague | 1 gram | Q12 hours for 10 days | |
| Endocarditis due to penicillin sensitive alpha and non-hemolytic streptococci | 1 gram | BID for 1 week, then 0.5 grams BID for the second week given with penicillin | |
| Enterococcal endocarditis | 1 gram | BID for 2 weeks, then 0.5 gram BID for an additional 4 weeks given with penicillin |
| Creatinine Clearance | Frequency |
| Crcl >50 ml/min | Q24 hours |
| Crcl 10-50 ml/min | Q24-72 hours |
| Crcl <10 ml/min | Q72-96 hours |
| Dose and Frequency |
| One-half of the normal dose is recommended as a supplement after dialysis |