Normal Dose|Renal Impairment|Hemodialysis
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| Indication | Dose | Frequency | Cost |
| Susceptible strains of staphylococcal or streptococcal endocarditis | 12-18 million units/day | divide dose Q4 hours for 4 weeks | $11.46/day |
| Susceptible strains of enterococcal endocarditis | 18-30 million units/day | divide dose Q4 hours for 4-6 weeks with an aminoglycoside | $11.46/day |
| Gas gangrene | 1-2 million units | Q2-3 hours | $22.92/day |
| Pregnant women-Group B Streptococci | 5 million units followed by 2.5 million units | Q4 hours until delivery | $11.46/day |
| Late syphilis | 2-4 million units | Q4 hours for 10 days | $11.46/day |
| Anthrax | 5 million units/day | given in divided doses until the infection is cured |
| Creatinine Clearance | Dose and Frequency |
| Crcl >50 ml/min | no dosage reduction is necessary |
| Crcl 10-50 ml/min | reduce dose to 75% of the normal dose at the usual dosing interval |
| Crcl <10 ml/min | reduce dose to 20% to 50% of the normal dose at the usual dosing interval |
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Dose and Frequency |
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A maintenance dose may be given to patients following hemodialysis |