Normal Dose|Renal Impairment|Hemodialysis
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| Indication | Dose | Frequency | Cost |
| Acute uncomplicated urinary tract infections | 100 or 250 mg | Q12 hours for 3 days | $6.62/day(po) |
| Mild to moderated urinary tract infections | 250 mg(po) or 200 mg (inj) | Q12 hours for 7-14 days | $6.62/day(po)
$25.06/day(inj) |
| Severe/complicated urinary tract infections | 500 mg(po) or 400 mg (inj) | Q12 hours for 7-14 days | $7.74/day(po)
$48.20/day(inj) |
| Mild /moderate lower respiratory tract infections | 500 mg(po) or 400 mg (inj) | Q12 hours for 7-14 days | $7.74/day(po)
$48.20/day(inj) |
| Severe/complicated lower respiratory tract infections | 750 mg(po)
400 mg (inj) |
Q12 hours for 7-14 days
Q8 hours for 7-14 days |
$7.74/day(po)
$72.30/day(inj) |
| Mild /moderate bone and joint infections | 500 mg(po) or 400 mg(inj) | Q12 hours for 4-6 weeks | $7.74/day(po)
$48.20/day(inj) |
| Severe/complicated bone and joint infections | 750 mg(po)
400 mg(inj) |
Q12 hours for 4-6 weeks
Q8 hours for 4-6 weeks |
$7.74/day(po)
$72.30/day(inj) |
| Mild/moderate skin and skin structure infections | 500 mg(po) or 400 mg(inj) | Q12 hours for 7-14 days | $7.74/day(po)
$48.20/day(inj) |
| Severe/complicated skin and skin structure infections | 750 mg(po)
400 mg(inj) |
Q12 hours for 7-14 days
Q8 hours for 7-14 days |
$7.74/day(po)
$72.30/day(inj) |
| Nosocomial pneumonia | 400 mg(inj) | Q8 hours | $72.30/day(inj) |
| Intra-abdominal-complicated | 500 mg(po) or 400 mg(inj) | Q12 hours for 7-14 days | $7.74/day(po)
$48.20/day(inj) |
| Acute sinusitis | 500 mg(po) or 400mg(inj) | Q12 hours for 10 days | $7.74/day(po)
$48.20/day(inj) |
| Chronic bacterial prostatitis | 500mg(po) or 400 mg(inj) | Q12 hours for 28 days | $7.74/day(po)
$48.20/day(inj) |
| Empirical therapy in febrile neutropenic patients | 400 mg(inj) | Q8 hours with piperacillin | $72.30/day(inj) |
| Infectious diarrhea | 500 mg(po) | Q12 hours for 5-7 days | $7.74/day(po) |
| Typhoid fever | 500 mg(po) | Q12 hours for 10 days | $7.74/day(po) |
| Inhalational anthrax | 500 mg(po) or 400 mg(inj) | Q12 hours for 60 days | $7.74/day(po)
$48.20/day(inj) |
| Creatinine Clearance | Dose and Frequency |
| Crcl >50 ml/min(po) | usual dose and dosage interval |
| Crcl >30 ml/min(inj) | usual dose and dosage interval |
| Crcl 30-50 ml/min(po) | 250-500 mg Q12 hours |
| Crcl 5-29 ml/min | 250-500 mg Q18 hours (po)
200 mg-400 mg Q18-24 hours (inj) |
| Dose | Frequency |
| 250-500 mg | Q24 hours after each dialysis |