Normal Dose|Renal Impairment|Hemodialysis
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| Indication | Dose | Frequency | Cost |
| Bacterial infections-general | 1-2 grams | Q24 hours | $41.83-$81.17/day |
| Endocarditis | 2 grams | Q24 hours for 4 weeks | $81.17/day |
| Uncomplicated meningitis caused by susceptible Haemophilus influenzae or Neisseria meningitidis | 2 grams | Q12 hours for 7 days | $162.34/day |
| Complicated meningitis caused by Streptococcus pneumoniae | 2 grams | Q12 hours for 10-14 days | $162.34/day |
| Meningitis caused by susceptible Enterobacteriaceae | 2 grams | Q12 hours for 21 days | $162.34/day |
| Febrile neutropenia | 2 grams | Q24 hours for 5 days or more plus an aminoglycoside for 2 days or more | $81.17/day |
| Urinary tract infections | 1 gram | Q24 hours | $41.83/day |
| Dose and Frequency |
| Dosing adjustments are not required in renal failure with doses up to 2 grams per day |
| Dose and Frequency |
| Ceftriaxone is not removed by hemodialysis, supplemental doses of the drug are unnecessary during or after dialysis |