Normal Dose|Renal Impairment|Hemodialysis
____________________________________________________________
| Indication | Dose | Frequency | Cost |
| Uncomplicated urinary tract infections | 500 mg | Q12 hours | $18.96/day |
| Infections caused by susceptible bacteria | 1 gram | Q8-12 hours | $28.44/day |
| Severe or complicated infections | 1 gram
2 grams |
Q8 hours
Q8-12 hours |
$28.44/day
$52.80/day |
| Life-threatening infections | 3-4 grams
2 grams |
Q8 hours
Q4 hours |
$105.60/day
$105.60/day |
| Septicemia | 6-12 grams | Q24 hours | $52.80-$105.60/day |
| Pelvic inflammatory disease caused by Neisseria gonorrhoeae, Escherichia coli, or Streptococcus agalactiae(group B streptococci) | 2 grams | Q8 hours(6 grams daily) | $52.80/day |
| Creatinine Clearance | Dose and Frequency | |
| Less severe infections | Life-threatening infections | |
| Crcl 79 to 50 ml/min | 500 mg Q8 hours | 750 mg to 1.5 grams Q8 hours |
| Crcl 49 to 5 ml/min | 250 mg to 500 mg Q12 hours | 500 mg to 1 gram Q12 hours |
| Crcl 4 to 0 ml/min | 500 mg Q48 hours or 250 mg Q24 hours | 500 mg to 1 gram Q48 hours or 500 mg Q24 hours |
| Dose and Frequency for less severe infections | Dose and Frequency for more severe infections |
| 500 mg Q48 hours; dose to be given at the end of
dialysis
250 mg Q24 hours; dose to be given at the end of dialysis |
500 mg to 1 gram Q48 hours; dose to be given at the end
of dialysis
500 mg Q24 hours; dose to be given at the end of dialysis |