Normal Dose|Renal Impairment|Hemodialysis
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| Indication | Dose | Frequency | Cost |
| Pneumococcal pneumonia | 500 mg | Q12 hours | $1.96/day |
| Mild infection caused by susceptible gram-positive cocci | 250 mg-500 mg | Q8 hours | $2.67/day |
| Moderate to severe infections | 500 mg-1 gram | Q6-8 hours | $3.56/day |
| Severe, life-threatening infections( endocarditis and septicemia) | 1 gram-1.5 gram | Q6 hours | $3.56-$7.12/day |
| Acute uncomplicated urinary tract infections | 1 gram | Q12 hours | $1.96/day |
| Creatinine Clearance | Dose and Frequency |
| Crcl => 55 ml/min | full dose |
| Crcl 35 -54 ml/min | full dose with at least 8 -hour intervals |
| Crcl 11-34 ml/min | 1/2 usual dose at 12-hour intervals |
| Crcl < 10 ml/min | 1/2 usual dose at 18 to 24- hour intervals |
| Dose | Frequency |
| 2 gram | to be given at the end of each dialysis |