Normal Dose|Renal Impairment|Hemodialysis
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| Indication | Dose | Frequency | Cost |
| Otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, staphylococci, and Streptococcus pyogenes | 250 mg | Q8 hours | $1.17/day |
| More serious infections or those caused by less susceptible organisms | 500 mg | Q8 hours | $2.34/day |
| Lower respiratory tract infections, including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus pyogenes | 250 mg | Q8 hours | $1.17/day |
| Acute bacterial exacerbations of chronic bronchitis or secondary bacterial infections of acute bronchitis caused by H.Influenzae, M. catarrhalis, or S. pneumoniae | 500 mg(extended release tablet) | Q12 hours for 7 days | |
| Cystic fibrosis to suppress the growth of Haemophilus influenzae in the respiratory tract | 250 -500 mg | Q8 hours | $2.34/day |
| Pharyngitis and/or tonsillitis caused by S. pyogenes | 375 mg (extended release tablet) | Q12 hours for 10 days | |
| Uncomplicated skin & skin structure infections caused by S. aureus | 375 mg(extended release tablet) | Q12 hours for 7-10 days | |
| Urinary tract infections , including pyelonephritis and cystitis, caused by Escherichia coli, Proteus mirabilis, Klebsiella spp., and coagulase-negative staphylococci | 250 mg | Q8 hours | $1.17/day |
| Creatinine Clearance | Dose and Frequency |
| Crcl 10 to 50 ml/min | 50 % to 100% of the normal dose |
| Crcl < 10 ml/min | 50 % of the normal dose |
| Dose | Frequency |
| 250 mg | dose should be given after hemodialysis |