TICARCILLIN/CLAVULANIC ACID

Normal Dose|Renal Impairment|Hemodialysis

Index

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Normal Dose

 

Indication Dose Frequency Cost
Systemic infections (in patients weighing>60 kg) 3.1 grams Q4-6 hours $61.02/day
Systemic infections (in patients weighing <60 kg) 200-300 mg/kg/day divide dose Q4-6 hours  
Urinary tract infections (in patients weighing >60 kg) 3.1 grams Q4-6 hours $61.02/day
Urinary tract infections(in patients weighing <60 kg) 200-300 mg/kg/day divide dose Q4-6 hours  
Cystic fibrosis with pulmonary infections caused by Staphylococcus aureus and either Pseudomonas aeruginosa or Haemophilus influenzae 3.1 grams Q6 hours $61.02/day
Gynecologic infections- moderate 200 mg/kg/day divide dose Q4-6 hours  
Gynecologic infections- severe 300 mg/kg/day divide dose Q4 hours  
Intra-abdominal infections (in patients weighing>60kg) 3.1 grams Q4-6 hours $61.02/day
Intra-abdominal infections(in patients weighing <60kg) 200-300 mg/kg/day divide dose Q4-6 hours  


Renal Impairment

 

Creatinine Clearance Dose and Frequency
Crcl > 60 ml/min 3.1 grams Q4 hours
Crcl 30-60 ml/min 2 grams Q4 hours
Crcl 10-30 ml/min 2 grams Q8 hours
Crcl <10 ml/min 2 grams Q12 hours
Crcl <10 ml/min with hepatic dysfunction 2 grams Q24 hours


Hemodialysis

Dose Frequency
2 grams Q12 hours supplemented with 3.1 grams after each dialysis

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